<p>Preface; Guenther Witzany.- </p><p>1. Revolutionary struggle for existence: introduction to four intriguing puzzles in virus research; Matti Jalasvuori.- </p><p>2. Quasispecies dynamics of RNA viruses; Miguel Angel Martínez et al.- </p><p>3. The origin of virions and virocells: the escape hypothesis revisited; Patrick Forterre, Mart Krupovic.- </p><p>4. Scratching the Surface of Biology's Dark Matter; Merry Youle et al.- </p><p>5. Virus universe: can it be constructed from a limited number of viral architectures; Hanna M. Oksanen et al.- </p><p>6. The addiction module as a social force; Luis Villarreal.- </p><p>7. Viral integration and consequences on host gene expression; Sébastien Desfarges, Angela Ciuffi.- </p><p>8. Persistent plant viruses: molecular hitchhikers or epigenetic elements?; Marilyn Roossinck.- </p><p>9. The concept of virus in the post-Megavirus era; Jean Michel Claverie, Chantal Abergel.- </p><p>10. Unpacking the baggage : Origin and Evolution of Giant Viruses; Jonathan Filee, Michael Chandler.- </p><p>11. Megavirales composing a fourth domain of life: Mimiviridae and Marseilleviridae; Philippe Colson, Didier Raoult.- </p><p>12. On viruses, bats and men: a natural history of food-borne viral infections; Harald Brussow.- </p><p>13. LTR retroelement-derived protein-coding genes and vertebrate evolution; Domitille Chalopin et al.- </p><p>14. Koala retrovirus endogenisation in action; Rachael Tarlington.- </p><p>15. The evolutionary interplay between exogenous and endogenous sheep betaretroviruses; Alessia Armezzani et al.- </p><p>16. Endogenous retroviruses and the epigenome ; Andrew B. Conley, I.King Jordan.- </p><p>17. From viruses to genes: syncytins; Philippe Pérot et al.- </p><p>18. Hepatitis G Virus or GBV-C: A Natural Anti-HIV Interfering Virus; Omar Bagasra et al.- </p><p>19. Salutary Contributions of Viruses to Medicine and Public Health; Steve Abedon.- </p><p>20. From Molecular Entities to Competent Agents: Viral Infection-Derived Consortia Act as Natural Genetic Engineers; Guenther Witzany.</p>