Therapeutic Enzymes: Function and Clinical Implications

Section 1: Production and characterization of therapeutic enzymes <p>Chapter 1. Introduction to therapeutic enzymes<br>Fuhrmann G, Leroux JC,&nbsp;Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Str. 10, HCI H 301, 8093, Zurich, Switzerland</p>

Chapter 2. Upstream processing technologies<br>Ian Marison,&nbsp;Dublin City University, Glasnevin, Dublin 9, Ireland<p></p>

<p>Chapter 3. Downstream processing technologies<br>N. Labrou,&nbsp;Department Biotechnology, University of Athens</p>

<p>Chapter 4. Enzyme Manufacturing Process and Quality Control Evaluations<br>Ingrid Markovic, Ph.D.,&nbsp;Laboratory of Biochemistry, Division of Therapeutic Proteins,&nbsp;Office of Biotechnology Products, Office of Pharmaceutical Science,&nbsp;Center for Drug Evaluation and Research, FDA</p>

<p>Chapter 5. Regulatory guidance in the production of therapeutic enzymes<br>John Geigert, PhD, RAC,&nbsp;BioPharmaceutical Quality Solutions</p>

<p>Chapter 6. Biophysical methods for the characterization of Enzyme Therapeutics<br>Bertrand Raynal Patrick England,&nbsp;CNRS-UMR3528, Institut Pasteur, Department of Structural Biology and Chemistry</p>

<p>Chapter 7. Clinical Development of a therapeutic enzyme<br>Baldo BA,&nbsp;11 Bent Street, Lindfield, NSW, 2070, Australia</p>

<p>Section 2: Engineering and delivery of therapeutic enzymes</p>

<p>Chapter 8. Chemical modifications of therapeutic proteins<br>Mark D. Distefano,&nbsp;Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA</p>

<p>Chapter 9. Formulation of therapeutic enzymes<br>Sathy V. Balu-Iyer,&nbsp;Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Amherst, NY14260, USA</p>

<p>Chapter 10. Engineering of therapeutic enzymes for improving activity<br>Georgiou, G,&nbsp;University of Texas, Austin</p>

<p>Chapter 11. Engineering of therapeutic enzymes for improving stability<br>Tokuriki N,&nbsp;Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada</p>

<p>Chapter 12. Design and engineering of deimmunized therapeutic enzymes<br>Griswold KE,&nbsp;Thayer School of Engineering, Dartmouth, Hanover, NH, United States</p>

<p>Chapter 13. Nanoparticles for delivery of therapeutic enzymes<br>Champion JA,&nbsp;Department of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia</p>

Chapter 14. Targeted delivery of therapeutic enzymes<br>Gianneschi NC,&nbsp;Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA<p></p>

<p>Chapter 15. Oral and inhalable enzyme therapies<br>Khosla C,&nbsp;Division of Biology, California Institute of Technology, Pasadena, California, USA</p>

Chapter 16. Regulatory issues<br>Anurag S. Rathore, Ph.D.,&nbsp;DBT Center of Excellence for Biopharmaceutical Technology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016, India<p></p>

<p>Section 3: Structure, indications and mechanisms for enzymes approved for human therapy</p>

<p>Chapter 17. Enzyme replacement therapies<br>Harmatz P,&nbsp;1UCSF Benioff Children's Hospital Oakland, Oakland, California</p>

<p>Chapter 18. Pharmacodynamics and pharmacokinetics issues of enzyme replacement therapy<br>Qi Y,&nbsp;BioMarin Pharmaceutical Inc., 105 Digital Dr, Novato, CA, 94949, USA</p>

<p>Chapter 19. Enzyme therapy for lysosomal storage disorders<br>Hollak CE,&nbsp;Department of Internal Medicine, Division of Endocrinology and Metabolism, SPHINX, Amsterdam Lysosome Center, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands</p>

<p>Chapter 20. Enzyme therapy for myocardial infarction<br>Kunamneni A,&nbsp;Center for Global Health, Department of Internal Medicine, University of New Mexico and New Mexico VA Health Care System, Albuquerque - 87108, New Mexico, USA</p>

<p>Chapter 21. Enzyme therapy for chronic gout<br>Shannon JA,&nbsp;Philadelphia College of Osteopathic Medicine, School of Pharmacy, Suwanee, GA, USA</p>

<p>Chapter 22. Enzyme therapy for tumor lysis syndrome<br>Lopez-Olivo MA,&nbsp;Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA</p>

<p>Chapter 23. Enzyme therapy for collagen-based disorders<br>Kaplan FT,&nbsp;Indiana Hand to Shoulder Center, 8501 Harcourt Rd, Indianapolis, IN 46260 USA</p>

<p>Chapter 24. Enzyme therapy for severe combined immunodeficiency disease<br>Onodera M,&nbsp;Department of Human Genetics, National Research Institute for Child Health and Development, Japan</p>

<p>Chapter 25. Enzyme therapy for detoxification of methotrexate<br>Wang A,&nbsp;The University of Texas MD Anderson Cancer Center, Houston, TX, USA</p>

<p>Chapter 26. Enzyme therapy vitreomacular adhesion<br>Rodríguez-Hurtado FJ,&nbsp;Servicio de Oftalmología, Hospital Virgen de las Nieves, Granada, España</p>

<p>Chapter 27. L-Asparaginase as anticancer agent<br>N. Labrou, Department Biotechnology, University of Athens</p>

<p>Chapter 28. Pancreatic enzyme replacement therapy<br>Berry AJ,&nbsp;University of Virginia Health System, Charlottesville, Virginia</p>

Section 4:&nbsp; Prospective and future therapeutic enzymes<p></p>

<p>Chapter 29. Enzymes in metabolic anticancer therapy<br>Claudia Scotti, Department of Experimental Medicine, Section of General Pathology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy</p>

<p>Chapter 30. L-Arginase for L-Arg depletion therapy in cancer<br>Feun LG,&nbsp;aSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida</p>

<p>Chapter 31. Methionine L-lyase for L-Met depletion therapy in cancer<br>Cavuoto P,&nbsp;CSIRO Food and Nutritional Sciences, P.O. Box 10041, Adelaide BC, SA 5000, Australia</p>

<p>Chapter 32. Enzyme therapy for celiac sprue<br>Freeman HJ,&nbsp;University of British Columbia, Department of Medicine (Gastroenterology) , Vancouver, BC , Canada</p>

<p>Chapter 33. Acid ceramidase<br>Schuchman EH,&nbsp;Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA</p>

<p>Chapter 34. Lysosomal acid lipase<br>Paton DM,&nbsp;University of Auckland, Auckland, New Zealand</p>

<p>Chapter 35. Alkaline phosphatase and hypophosphatasia<br>Millán JL,&nbsp;Sanford Children's Health Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA</p>

<p>Chapter 36. Enzybiotics: Antibiotic enzymes as drugs and therapeutics<br>Briers Y,&nbsp;Department of Applied Biosciences, Ghent University, Valentin Vaerwyckweg 1, 9000 Ghent, Belgium</p>

<p>Chapter 37. Anti-inflammatory enzymes<br>Muzykantov VR.,&nbsp;Department of Pharmacology and Center for Translational Targeted Therapeutics and Nanomedicine of the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</p>

<p>Chapter 38. Phenylalanine ammonia lyase for the treatment of phenylketonuria<br>Blau N,&nbsp;University Children's Hospital, Division of Inborn Metabolic Diseases , Im Neuenheimer Feld 669, Heidelberg 69120 , Germany</p>

<p>Chapter 39. Clinical applications of Hyaluronidase<br>Gerber PA,&nbsp;Department of Dermatology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.</p>

<p>Chapter 40. Superoxide dismutase and oxidative stress modulation<br>Carillon J,&nbsp;Nutrition & Métabolisme, UMR 204 NutriPass Prévention des Malnutritions et des Pathologies Associées, Université Montpellier 1-2, Montpellier, France.</p>

<p>Chapter 41. Organophosphate hydrolases as catalytic bioscavengers<br>Masson P,&nbsp;Neuropharmacology Laboratory, Kazan Federal University, 18 Kremlevskaia St., 48000 Kazan, Russian Federation. Electronic address: pym.masson@free.fr.&nbsp;</p>

<p>Chapter 42. Novel therapeutic proteases<br>Daugherty PS,&nbsp;Department of Chemical Engineering, University of California, Santa Barbara, California 93106.</p>

<p>Chapter 43. Genome-editing enzymes<br>Liu, DR.,&nbsp;Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts, USA</p><p>Chapter 44. Gene therapy for enzyme deficiency: current status and future prospects<br>McIvor RS,&nbsp;Department of Genetics, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA.</p>